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PPAR Delta Mouse Monoclonal Antibody (1D7)

PPAR Delta Mouse Monoclonal Antibody (1D7)

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Specification

Product name PPAR Delta Mouse Monoclonal Antibody (1D7)
Immunogen Recombinant Protein of PPAR Delta of PPAR Delta
Host Mouse
Reactivity Human, Mouse, Rat
Applications IHC-P
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).
Clonality Monoclonal
Preparation method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Alternative Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background PPARD (peroxisome proliferator activated receptor delta) encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of PPARD is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Gene ID 5467
Alternative Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta
Others PPAR Delta protein detects endogenous levels of PPAR Delta.
Accession Q03181
Observed Band(KD) 50

Image & description

Fig.1. Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using PPAR Delta Mouse mAb diluted at 1:200.

Fig.1. Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using PPAR Delta Mouse mAb diluted at 1:200.

Fig.2. Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using PPAR Delta Mouse mAb diluted at 1:200.

Fig.2. Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using PPAR Delta Mouse mAb diluted at 1:200.

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