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MLKL Polyclonal Antibody

MLKL Polyclonal Antibody

Views(18) Publications(0) Catalog no(ABP51801)
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Specification

Product name MLKL Polyclonal Antibody
Immunogen Synthesized peptide derived from the N-terminal region of human MLKL at AA range: 40-120
Host Rabbit
Reactivity Human
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative MLKL; Mixed lineage kinase domain-like protein

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background MLKL belongs to the protein kinase superfamily. Mixed lineage kinase domain-like protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. Mixed lineage kinase domain-like protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Gene ID 197259
Alternative MLKL; Mixed lineage kinase domain-like protein
Others MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.
Accession Q8NB16
Observed Band(KD) 55

Image & description

Fig. Western Blot analysis of various cells using MLKL Polyclonal Antibody diluted at 1:500.

Fig. Western Blot analysis of various cells using MLKL Polyclonal Antibody diluted at 1:500.

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