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mGluR-4 Polyclonal Antibody

mGluR-4 Polyclonal Antibody

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Specification

Product name mGluR-4 Polyclonal Antibody
Immunogen Synthesized peptide derived from the C-terminal region of human mGluR-4 at AA range: 820-900
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative GRM4; GPRC1D; MGLUR4; Metabotropic glutamate receptor 4; mGluR4

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for GRM4.
Gene ID 2914
Alternative GRM4; GPRC1D; MGLUR4; Metabotropic glutamate receptor 4; mGluR4
Others mGluR-4 Polyclonal Antibody detects endogenous levels of mGluR-4 protein.
Accession Q14833
Observed Band(KD) 100

Image & description

Fig.1. Western Blot analysis of various cells using mGluR-4 Polyclonal Antibody diluted at 1:500.

Fig.1. Western Blot analysis of various cells using mGluR-4 Polyclonal Antibody diluted at 1:500.

Fig.2. Western Blot analysis of 293 cells using mGluR-4 Polyclonal Antibody diluted at 1:500.

Fig.2. Western Blot analysis of 293 cells using mGluR-4 Polyclonal Antibody diluted at 1:500.

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