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Integrin α4 Polyclonal Antibody

Integrin α4 Polyclonal Antibody

Views(680) Publications(0) Catalog no(ABP52979)
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Specification

Product name Integrin α4 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Integrin α4
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background ITGA4 encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.
Gene ID 3676
Alternative ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d
Others Integrin α4 Polyclonal Antibody detects endogenous levels of Integrin α4 protein.
Accession P13612
Observed Band(KD) 120

Image & description

Fig.1. Western Blot analysis of K562 cells using Integrin α4 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.1. Western Blot analysis of K562 cells using Integrin α4 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.2. Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:100.

Fig.2. Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:100.

Fig.3. Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:100.

Fig.3. Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:100.

Fig.4. Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:100.

Fig.4. Immunohistochemical analysis of paraffin-embedded human-lymph, antibody was diluted at 1:100.

Fig.5. Immunohistochemical analysis of paraffin-embedded Mouse-spleen, antibody was diluted at 1:100.

Fig.5. Immunohistochemical analysis of paraffin-embedded Mouse-spleen, antibody was diluted at 1:100.

Fig.6. Immunohistochemical analysis of paraffin-embedded Mouse-spleen, antibody was diluted at 1:100.

Fig.6. Immunohistochemical analysis of paraffin-embedded Mouse-spleen, antibody was diluted at 1:100.

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