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Human IFN-α2 protein

Human IFN-α2 protein

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Product name Human IFN-α2 protein
Immunogen PRP100327
Sequence Amino acid sequence derived from human IFNA2 (NP_000596.2) (Cys24-Glu188) was expressed.
Activity Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The EC50 for this effect is typically 0.6-4.2pg/mL.
Protein length The recombinant human IFNA2 consists 165 amino acids and predicts a molecular mass of 19.3 kDa.
Preparation method Yeast
Purity > 95 % as determined by SDS-PAGE.
Alternative IFN-alphaA; IFNA; IFNA2B; IFNAB; INFA2; Interferon alpha 2; Interferon alpha-2; IFNA2

Product Properties

Formulation Lyophilized from sterile PBS, pH 7.4.
Molecular weight 19.3 kDa
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IFN alpha 2 protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized Human IFN-α2 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.78% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping The product is shipped at ambient temperature.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Human interferon α-2 (IFNα2) is a cytokine belonging to the family of type I IFNs. IFNα2 is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. The first description of IFNs as a cellular agent interfering with viral replication was made by Alick Isaacs and Jean Lindenmann in 1957. The history of this finding was recently reviewed. There are 3 types of IFNs: Interferon type I, Interferon type II and Interferon type III. The type II IFN, also called IFNγ, is produced by specific cells of the immune system. Unlike type I and type III IFNs, IFNγ has only a modest role in directly restricting viral infections. Type I and type III IFNs act similarly. However, the action of type III IFNs, also known as IFNλ, is limited to epithelial cells while type I IFNs act on all body's cells.
Gene ID 3440
Alternative IFN-alphaA; IFNA; IFNA2B; IFNAB; INFA2; Interferon alpha 2; Interferon alpha-2; IFNA2
Accession NP_000596.2

Image & description

Fig.SDS-PAGE analysis of Human IFN alpha 2 protein.

Fig.SDS-PAGE analysis of Human IFN alpha 2 protein.

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