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Human CD40/TNFRSF5 protein, His tag (Animal-Free)

Human CD40/TNFRSF5 protein, His tag (Animal-Free)

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Specification

Product name Human CD40/TNFRSF5 protein, His tag (Animal-Free)
Sequence Amino acid sequence derived from human CD40 protein (NP_001241.1, Met1-Arg193) was expressed with a polyhistidine tag at the C-terminus.
Protein length The recombinant human CD40 protein consists of 179 amino acids and predicts a molecular mass of 20 kD.The apparent molecular mass of the human CD40 is approximately 25-33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Preparation method HEK 293 Cells
Purity >95% as determined by SDS-PAGE
Alternative B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

Product Properties

Formulation Lyophilized from sterile PBS, pH 7.4.
Features & Benefits Endotoxin: < 1 EU per µg of the protein as determined by the LAL method.
Molecular weight 20kDa
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized human CD40 protein in the buffer which we provide not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized Human CD40/TNFRSF5 protein, His tag (Animal-Free)should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.114% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping The product is shipped at ambient temperature.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. The involvement of CD40 in chronic immune activation has resulted in CD40 being proposed as a therapeutic target for a range of chronic inflammatory diseases. CD40 antagonists are currently being explored for the treatment of autoimmune diseases and several anti-CD40 agonist mAbs have entered clinical development for oncological indications.
Gene ID 958
Alternative B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Accession P25942

Image & description

Fig.SDS-PAGE analysis of Human CD40/TNFRSF5 protein, His tag

Fig.SDS-PAGE analysis of Human CD40/TNFRSF5 protein, His tag

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