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DNA pol ι Polyclonal Antibody

DNA pol ι Polyclonal Antibody

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Specification

Product name DNA pol ι Polyclonal Antibody
Immunogen Synthesized peptide derived from the C-terminal region of human DNA pol ι at AA rangle: 610-690
Host Rabbit
Reactivity Human
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative POLI; RAD30B; DNA polymerase iota; Eta2; RAD30 homolog B

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background POLI (Polymerase (DNA) Iota) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Fanconi anemia pathway. GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLH. rror-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Gene ID 11201
Alternative POLI; RAD30B; DNA polymerase iota; Eta2; RAD30 homolog B
Others DNA pol ι Polyclonal Antibody detects endogenous levels of DNA pol ι protein.
Accession Q9UNA4
Observed Band(KD) 85

Image & description

Fig. Western Blot analysis of HeLa cells using DNA pol ι Polyclonal Antibody.

Fig. Western Blot analysis of HeLa cells using DNA pol ι Polyclonal Antibody.

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