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Cortactin Polyclonal Antibody

Cortactin Polyclonal Antibody

Views(77) Publications(0) Catalog no(ABP54118)
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Specification

Product name Cortactin Polyclonal Antibody
Immunogen Synthesized peptide derived from human Cortactin around the non-phosphorylation site of Y446
Host Rabbit
Reactivity Human
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The cortactin is localized in the cytoplasm and in areas of the cell-substratum contacts. CTTN has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Gene ID 2017
Alternative CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1
Others Cortactin Polyclonal Antibody detects endogenous levels of Cortactin protein.
Accession Q14247
Observed Band(KD) 80

Image & description

Fig. Western Blot analysis of HeLa cells using Cortactin Polyclonal Antibody.

Fig. Western Blot analysis of HeLa cells using Cortactin Polyclonal Antibody.

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