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Cleaved-Notch 2 (A1734) Polyclonal Antibody

Cleaved-Notch 2 (A1734) Polyclonal Antibody

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Specification

Product name Cleaved-Notch 2 (A1734) Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Notch 2 at AA range: 1690-1770
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background NOTCH2 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. The notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. The notch 2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID 4853
Alternative NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2
Others Cleaved-Notch 2 (A1734) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to A1734.
Accession Q04721
Observed Band(KD) 79

Image & description

Fig. Western Blot analysis of Jurkat cells using Cleaved-Notch 2 (A1734) Polyclonal Antibody diluted at 1:2000.

Fig. Western Blot analysis of Jurkat cells using Cleaved-Notch 2 (A1734) Polyclonal Antibody diluted at 1:2000.

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