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Casein Kinase Iγ2 Polyclonal Antibody

Casein Kinase Iγ2 Polyclonal Antibody

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Specification

Product name Casein Kinase Iγ2 Polyclonal Antibody
Immunogen Synthesized peptide derived from the N-terminal region of human Casein Kinase Iγ2 at AA rangle: 10-90
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IF, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CSNK1G2; CK1G2; Casein kinase I isoform gamma-2; CKI-gamma 2

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.
Gene ID 1455
Alternative CSNK1G2; CK1G2; Casein kinase I isoform gamma-2; CKI-gamma 2
Others Casein Kinase Iγ2 Polyclonal Antibody detects endogenous levels of Casein Kinase Iγ2 protein.
Accession P78368
Observed Band(KD) 47

Image & description

Fig. Western Blot analysis of HeLa cells using Casein Kinase Iγ2 Polyclonal Antibody.

Fig. Western Blot analysis of HeLa cells using Casein Kinase Iγ2 Polyclonal Antibody.

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