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Anti-α-Tubulin Monoclonal Antibody (3G5), AbFluor™ 488 Conjugated

Anti-α-Tubulin Monoclonal Antibody (3G5), AbFluor™ 488 Conjugated

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Specification

Product name Anti-α-Tubulin Monoclonal Antibody (3G5), AbFluor™ 488 Conjugated
Immunogen Recombinant Protein
Host Mouse
Reactivity Human, Mouse, Rat
Applications IF, IHC-P
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:50-1:300), IF (1:200).
Clonality Monoclonal
Preparation method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Conjugate AbFluor™ 488
Alternative TUBA1A; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain

Product Properties

Formulation Liquid solution
Storage buffer Liquid in PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in the dark.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that TUBA1A expression is predominantly found in morphologically differentiated neurologic cells. TUBA1A is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID 7846/10376
Alternative TUBA1A; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
Accession Q71U36/P68363

Image & description

Fig. AbFluor™ 488 (λEX/λEm: 490/515 nm) is a green fluorescent dye optimally excitable by the 488 nm argon laser line, which is super alternative to FITC, Oregon Green 488, FAM, Cy2, Dylight 488 and Alexa Fluor 488.

Fig. AbFluor™ 488 (λEX/λEm: 490/515 nm) is a green fluorescent dye optimally excitable by the 488 nm argon laser line, which is super alternative to FITC, Oregon Green 488, FAM, Cy2, Dylight 488 and Alexa Fluor 488.

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