| Product name | β-Catenin Monoclonal Antibody |
| Immunogen | Synthetic Peptide |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-P, WB |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000), IHC-P (1:200). |
| Clonality | Monoclonal |
| Preparation method | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
| Alternative | CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 92 KD |
| Storage buffer | PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1. |
| Gene ID | 1499 |
| Alternative | CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin |
| Others | The antibody detects endogenous β-Catenin proteins. |
| Accession | P35222 |
Fig.1. Western blot analysis of 1) hela, 2) 293T, 3) MCF7, 4) Mouse Brain tissue, 5) Rat LiverTissue, diluted at 1:2000.
Fig.2. IHC-P staining of human breast cancer tissue, diluted at 1:200.
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1.The species of antibody reactivity should be the sample species that can be matched normally after Abbkine R&D experts have passed strict scientific verification. If your sample is not within the range of reactivity, in order to improve the efficiency and results of your experiment, it is not suggested to try other species. Otherwise, it may lead to sample mismatch and affect the effect of your experiment.
2.Please aliquot the antibody received as soon as possible and store it at -20℃, avoid repeated freezing and thawing, and use it within one year.
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