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CheKine™ Xanthine Oxidase Assay Kit, a great tool for study of hyperuricemia

Xanthine oxidase is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species. These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. These enzymes play an important role in the catabolism of purines in some species, including humans. Xanthine oxidase (XO, EC 1.17.3.2 ) is present in appreciable amounts in the liver and jejunum in healthy individuals. Most of the protein in the liver exists in a form with xanthine dehydrogenase activity, but it can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. In various liver disorders, XO is released into circulation. Therefore, determination of serum XO level serves…

2019-07-24 1400 views

CheKine™ Lactate Assay Kit, fast quantitative determination of L (+)-Lactate in various samples

Lactate (CH3CH(OH)COO-) is a metabolic compound formed in animals by the action of the enzyme lactate dehydrogenase. Lactate is produced in proliferating cells during anaerobic conditions such as exercise. Abnormally high concentrations of lactate have been related to pathological conditions such as cancer, diabetes, and lactate acidosis. L(+)-Lactate is the major lactate stereoisomer formed in human intermediary metabolism and is present in blood at levels of around 1-2 mmol/L. D(-)-Lactate can also be found in blood but only at about 1-5% of the concentration of L(+)-Lactate. Lactic acid is the end product of glycolysis in the body, which can be produced when tissue hypoxia or pyruvic acid is not oxidized in time. Usually, the lactic acid obtained from metabolism does…

2019-07-16 3086 views

Want High accuracy and specificity? Yes, it’s Abbkine CheKine™ Catalase (CAT) Activity Assay Kit with great value

【Background】 Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals). It catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting the cell from oxidative damage by reactive oxygen species (ROS). Likewise, catalase has one of the highest turnover numbers of all enzymes; one catalase molecule can convert millions of hydrogen peroxide molecules to water and oxygen each second. Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals). It catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting the cell from…

2019-06-17 1576 views

Observing three-dimensional dynamics of the nucleus in live cells, Abbkine will give you great experiences !

Live-cell imaging technique allows real-time examination of almost every aspect of cellular function under normal and experimental conditions, so it is especially popular with cytology researchers. Abbkine TraKine™ Pro is a series of cell-permeable organic fluorescent probes which can selectively recognize and label organelles. Currently, we launched the staining kits involve tubulin, lysosome, mitochondrion and nuclei. This paper introduces the TraKine™ Pro Live-cell Nuclei Staining kit (Deep Red Fluorescence with Super Resolution). Function of nucleus The nucleus is the largest and most important cell structure in eukaryotic cells, mainly composed of nuclear envelope, chromatin, nuclear skeleton, nucleolus and nucleosome. Nuclear membrane is a two-layer membrane that completely encloses the nucleus and separates the material within the membrane from the cytoplasm…

2019-06-14 1466 views

Caspase(1,2,3,4,6,8,9) Assay Kit- Simple and convenient, to boost your apoptosis study

【Tips】If you are studying whether a certain drug can trigger apoptosis which relys on the caspase related pathway, and want to detect the activity of caspase, this article is suitable for you! This article is especially fit for researchers who are working hard to benefit the mankind. 【Background】 Caspases(cysteine-aspartic proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. The cascade reaction caused by caspases is a central part of the apoptotic process, and its activation mainly includes the mitochondria-dependent pathway and the death receptor-mediated signal transduction pathway. The downstream caspases are then activated, leading to apoptosis by cleavage of specific substrates. Inhibition of apoptotic function will lead to…

2019-06-05 1759 views

Abbkine newly released Selected Primary Antibody will shock you!

Abbkine strongly launched selected primary antibody with high quality control, which will be your reliable choice. The selected primary antibody involves most of the hot target research areas, and through multiple rigorous quality controls, to meet your high-quality requirements.   Thanks for the trust and support from all the new and old customers, Abbkine now launches new products one-stop promotion, matching the top selling products, buy one get one! With bulk stock, the product can be sent immediately after payment.   Promotion Details are as follows:   Promotion time: From now to December 31th, 2019   Contents: Selected Primary Antibody one-stop matching service, buy one get one! (involve the hot target areas such as Apoptosis, Signal Transduction, Neuroscience, and so…

2019-04-09 3056 views

TraKine™ Pro Mitochondrion live-cell Fluorescence Probe-I just want to surpass MitoTracker®!

【REVIEW】: TraKine™ Pro Live-cell Fluorescence Tool-Perfect compatibility with long-term super-resolution fluorescence imaging TraKine™ Pro Live-cell Tubulin Staining kit-Your Best Choice for Cytoskeleton Study Living cell staining, super-resolution Lysosome tracing Extensive research has indicated that intracellular organelles are integrated into cellular networks and collaborate on various cellular tasks rather than acting as isolated entities. Specialized membrane contact sites are formed between organelles, providing distinct spatial regions for executing and regulating their functions. Mitochondria is crucial dynamic organelles that participate extensively in many important cellular processes. Its dysfunction has been implicated in diverse diseases such as neurodegenerative disorders, cancer, and cardiovascular diseases. Capturing the dynamic process of subcellular organelles in living cells is crucial to the study of disease mechanism. The limitations…

2019-03-25 2956 views

Living cell staining, super-resolution Lysosome tracing

【REVIEW】: TraKine™ Pro Live-cell Fluorescence Tool-Perfect compatibility with long-term super-resolution fluorescence imaging TraKine™ Pro Live-cell Tubulin Staining kit-Your Best Choice for Cytoskeleton Study Lysosome is an important organelle in animal cells. Its integrity is closely related to animal physiology and pathology. Lysosomes are vesicle-like organelles surrounded by a single membrane and containing a variety of acidic hydrolases. Their main function is to carry out intracellular digestion and specialize in decomposing various exogenous and endogenous macromolecular substances. Lysosomes in cells are heterogeneous, and the size and types of hydrolytic enzymes contained in lysosomes may vary greatly. The marker enzyme is acid phosphatase. Recent studies have found that phagocytes and lysosomes have bidirectional signaling functions. The ability of lysosomes to move towards…

2019-03-15 2415 views

TraKine™ Pro Live-cell Tubulin Staining kit-Your Best Choice for Cytoskeleton Study

【Review 】 TraKine™ Pro Live-cell Fluorescence Tool-Perfect compatibility with long-term super-resolution fluorescence imaging As soon as the Abbkine TraKine™ Pro fluorescent dyes were released, they received high attention from living cell imaging researchers all over the world. With extremely high specificity, the probes can last for several hours in living cells, which is particularly suitable for studying the dynamics and interactions of subcellular structures in live cells for super-resolution imaging. In eukaryotes, microtubules are one of the main components of cytoskeleton. Cytoskeleton is not only involved in supporting cells, but also related to almost all forms of cell movements, such as cell migration, transport of organelles and macromolecules. In addition, it is closely related to signal transduction and cell division.…

2019-03-11 5130 views

TraKine™ Pro Live-cell Fluorescence Tool-Perfect compatibility with long-term super-resolution fluorescence imaging

Combining genetic marker method with small and bright probes that can be controlled by light-controlled switches will be a very ideal method to develop molecular-level ultra-high resolution imaging in the future. - Xiaowei Zhuang (Discoveries of novel cellular structures using STORM) Inspired by academician Xiaowei Zhuang, Abbkine TraKine™ Pro series of fluorescent dyes came into being. TraKine™ Pro is series of long-term super-resolution cell staining imaging portfolio for labeling subcellular structures of live and fixed cells. TraKine™ Pro proprietary excellent fluorescent dyes span the full UV-visible and near IR spectrum. This release of the TraKine™ Pro series featured hot research targets, including, Tubulin: One of the important components of eukaryotic cytoskeleton, plays an important role in maintaining cell morphology, cell…

2019-03-01 4709 views